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Gene expression profiles of the one-carbon metabolism pathway.

Journal of genetics and genomics = Yi chuan xue bao - 1 May 2009

Lee Yin Leng, Xu Xinran, Wallenstein Sylvan, Chen Jia

Abstract excerpt

One-carbon metabolism plays a critical role in both DNA methylation and DNA synthesis. Accumulating evidence has shown that interruptions of this pathway are associated with many disease outcomes including cardiovascular diseases and cancers. Mechanistic studies have been performed on genetic polymorphisms involved in one-carbon metabolism. However, expression profiles of these inter-related genes are not...

Topics

Cells, Cultured
Female
Gene Dosage
Gene Expression Profiling
Genetic Variation
Humans
Lymphocytes
Male
Metabolic Networks and Pathways
One-Carbon Group Transferases
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19447375
DOI: 10.1016/S1673-8527(08)60115-0
PMCID: PMC2684624

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