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Article

Genetic variations in the one-carbon metabolism pathway genes and susceptibility to hepatocellular carcinoma risk: a case-control study.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Feb 2015

Zhang Heng, Liu Chunhe, Han Yu-Chen, Ma Zuohong, Zhang Haiyan, Ma Yinan, Liu Xiaofang

Abstract excerpt

Hepatocellular carcinoma (HCC) is the sixth common cancer and the third common cause of cancer mortality worldwide. However, the exact molecular mechanism of HCC remains uncertain. Many enzymes are involved in one-carbon metabolism (OCM), and single nucleotide polymorphisms (SNPs) in the corresponding genes may play a role in liver carcinogenesis. In this study, we enrolled 1500 HCC patients and 1500 cancer-free...

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Source

Identifiers

PMID: 25318605
DOI: 10.1007/s13277-014-2725-z

Genes

GART
MTRR
OCM
MTHFR
CBS
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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