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Article

One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation.

PloS one - 1 Jan 2017

Moruzzi Sara, Guarini Patrizia, Udali Silvia, Ruzzenente Andrea, Guglielmi Alfredo, Conci Simone, Pattini Patrizia, Martinelli Nicola, Olivieri Oliviero, Tammen Stephanie A, Choi Sang-Woon, Friso Simonetta

Abstract excerpt

Several polymorphic gene variants within one-carbon metabolism, an essential pathway for nucleotide synthesis and methylation reactions, are related to cancer risk. An aberrant DNA methylation is a common feature in cancer but whether the link between one-carbon metabolism variants and cancer occurs through an altered DNA methylation is yet unclear. Aims of the study were to evaluate the frequency of one-carbon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28968444
DOI: 10.1371/journal.pone.0185792
PMCID: PMC5624642

Genes

MTHFD1
BHMT
DHFR
MTHFR
MTR
MTRR
RFC1
SHMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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