Article
Functional variants of the 5-methyltetrahydrofolate-homocysteine methyltransferase gene significantly increase susceptibility to prostate cancer: Results from an ethnic Han Chinese population.
Scientific reports - 3 Nov 2016
Qu Yuan-Yuan, Zhou Shu-Xian, Zhang Xuan, Zhao Rui, Gu Cheng-Yuan, Chang Kun, Yang Xiao-Qun, Gan Hua-Lei, Dai Bo, Zhang Hai-Liang, Shi Guo-Hai, Zhu Yao, Ye Ding-Wei, Zhao Jian-Yuan
Abstract excerpt
Aberrant DNA methylation has been implicated in prostate carcinogenesis. The one-carbon metabolism pathway and related metabolites determine cellular DNA methylation and thus is thought to play a pivotal role in PCa occurrence. This study aimed to investigate the contribution of genetic variants in one-carbon metabolism genes to prostate cancer (PCa) risk and the underlying biological mechanisms. In this...
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