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Article

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.

Molecular cell - 18 Feb 2005

Fukuhara Noemi, Ebert Judith, Unterholzner Leonie, Lindner Doris, Izaurralde Elisa, Conti Elena

Abstract excerpt

In metazoa, regulation of the phosphorylation state of UPF1 is crucial for nonsense-mediated mRNA decay (NMD), a process by which aberrant mRNAs containing nonsense mutations are degraded. UPF1 is targeted for dephosphorylation by three related proteins, SMG5, SMG6, and SMG7. We report here the crystal structure of the N-terminal domain of SMG7. The structure reveals that SMG7 contains a 14-3-3-like domain....

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Source

Identifiers

PMID: 15721257
DOI: 10.1016/j.molcel.2005.01.010

Genes

SMG7
UPF1
SMG5
SMG6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.PMID 15721257Read ↗

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