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Article

In Vitro Cross-Linking MS Reveals SMG1-UPF2-SMG7 Assembly as Molecular Partners within the NMD Surveillance.

International journal of molecular sciences - 10 Mar 2024

Padariya Monikaben, Vojtesek Borivoj, Hupp Ted, Kalathiya Umesh

Abstract excerpt

mRNAs containing premature stop codons are responsible for various genetic diseases as well as cancers. The truncated proteins synthesized from these aberrant mRNAs are seldom detected due to the nonsense-mediated mRNA decay (NMD) pathway. Such a surveillance mechanism detects most of these aberrant mRNAs and rapidly destroys them from the pool of mRNAs. Here, we implemented chemical cross-linking mass...

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Identifiers

PMID: 38542156
DOI: 10.3390/ijms25063182
PMCID: PMC10969982

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In Vitro Cross-Linking MS Reveals SMG1-UPF2-SMG7 Assembly as Molecular Partners within the NMD Surveillance.PMID 38542156Read ↗

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