Article
New aQTL SNPs for the CYP2D6 identified by a novel mediation analysis of genome-wide SNP arrays, gene expression arrays, and CYP2D6 activity.
BioMed research international - 1 Jan 2013
Jiang Guanglong, Chakraborty Arindom, Wang Zhiping, Boustani Malaz, Liu Yunlong, Skaar Todd, Li Lang
Abstract excerpt
BACKGROUND: The genome-wide association studies (GWAS) have been successful during the last few years. A key challenge is that the interpretation of the results is not straightforward, especially for transacting SNPs. Integration of transcriptome data into GWAS may provide clues elucidating the mechanisms by which a genetic variant leads to a disease. METHODS: Here, we developed a novel mediation analysis...
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