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Article

A functional ancestry-linked regulatory haplotype influences CYP2D6 expression.

The pharmacogenomics journal - 17 Feb 2026

McCoy Michael

Abstract excerpt

Cytochrome P450 (CYP) enzymes metabolize 70-80% of therapeutic agents, yet regulatory variants affecting drug metabolism remain poorly characterized across populations. Although numerous studies have examined coding variants in pharmacogenes, comprehensive analysis of regulatory variation across tissues and ancestries is lacking. Expression quantitative trait loci (eQTLs) for 54 CYP genes were analyzed using GTEx...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41702878
DOI: 10.1038/s41397-026-00398-1
PMCID: PMC12913022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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