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Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.

Genome research - 1 Aug 2010

Yang Xia, Zhang Bin, Molony Cliona, Chudin Eugene, Hao Ke, Zhu Jun, Gaedigk Andrea, Suver Christine, Zhong Hua, Leeder J Steven, Guengerich F Peter, Strom Stephen C, Schuetz Erin, Rushmore Thomas H, Ulrich Roger G, Slatter J Greg, Schadt Eric E, Kasarskis Andrew, Lum Pek Yee

Abstract excerpt

Liver cytochrome P450s (P450s) play critical roles in drug metabolism, toxicology, and metabolic processes. Despite rapid progress in the understanding of these enzymes, a systematic investigation of the full spectrum of functionality of individual P450s, the interrelationship or networks connecting them, and the genetic control of each gene/enzyme is lacking. To this end, we genotyped, expression-profiled, and...

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PMID: 20538623
DOI: 10.1101/gr.103341.109
PMCID: PMC2909567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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