Article

Co-occurring eQTLs and mQTLs: detecting shared causal variants and shared biological mechanisms

2016-12-15

Abstract excerpt

Inherited genetic variation impacts local gene expression and DNA methylation in humans. Expression and methylation quantitative trait loci (cis-eQTLs and cis-mQTLs) often occur at the same genomic location, suggesting a common causal variant and shared mechanism. Using DNA and RNA from peripheral blood of Bangladeshi individuals, we use “co-localization” methods to identify 3,695 eQTL-mQTL pairs that are likely t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 480b0da0-f8c0-5472-821c-8b6503f53226
DOI: 10.1101/094656

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Co-occurring eQTLs and mQTLs: detecting shared causal variants and shared biological mechanismsDOI 10.1101/094656Read

Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms.Semantic proximity Read

Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians.Semantic proximity Read

Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysisSemantic proximity Read

Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis.Semantic proximity Read

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits.Semantic proximity Read

Leveraging DNA methylation quantitative trait loci to characterize the relationship between methylomic variation, gene expression and complex traitsSemantic proximity Read

Quantifying mediation between omics layers and complex traitsSemantic proximity Read

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inferenceSemantic proximity Read

Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits.Semantic proximity Read

Pervasive correlations between causal disease effects of proximal SNPs vary with functional annotations and implicate stabilizing selectionSemantic proximity Read

Dissecting the colocalized GWAS and eQTLs with mediation analysis for high-dimensional exposures and confounders.Semantic proximity Read

New aQTL SNPs for the CYP2D6 identified by a novel mediation analysis of genome-wide SNP arrays, gene expression arrays, and CYP2D6 activity.Semantic proximity Read