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Article

Simultaneous test and estimation of total genetic effect in eQTL integrative analysis through mixed models.

Briefings in bioinformatics - 10 Mar 2022

Wang Ting, Qiao Jiahao, Zhang Shuo, Wei Yongyue, Zeng Ping

Abstract excerpt

Integration of expression quantitative trait loci (eQTL) into genome-wide association studies (GWASs) is a promising manner to reveal functional roles of associated single-nucleotide polymorphisms (SNPs) in complex phenotypes and has become an active research field in post-GWAS era. However, how to efficiently incorporate eQTL mapping study into GWAS for prioritization of causal genes remains elusive. We herein...

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PMID: 35212359
DOI: 10.1093/bib/bbac038

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