Article
Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms.
Nature communications - 23 Feb 2018
Pierce Brandon L, Tong Lin, Argos Maria, Demanelis Kathryn, Jasmine Farzana, Rakibuz-Zaman Muhammad, Sarwar Golam, Islam Md Tariqul, Shahriar Hasan, Islam Tariqul, Rahman Mahfuzar, Yunus Md, Kibriya Muhammad G, Chen Lin S, Ahsan Habibul
Abstract excerpt
Inherited genetic variation affects local gene expression and DNA methylation in humans. Most expression quantitative trait loci (cis-eQTLs) occur at the same genomic location as a methylation QTL (cis-meQTL), suggesting a common causal variant and shared mechanism. Using DNA and RNA from peripheral blood of Bangladeshi individuals, here we use co-localization methods to identify eQTL-meQTL pairs likely to share...
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