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Article

Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis.

Genome research - 1 Nov 2017

Yang Fan, Wang Jiebiao, Pierce Brandon L, Chen Lin S

Abstract excerpt

The impact of inherited genetic variation on gene expression in humans is well-established. The majority of known expression quantitative trait loci (eQTLs) impact expression of local genes (cis-eQTLs). More research is needed to identify effects of genetic variation on distant genes (trans-eQTLs) and understand their biological mechanisms. One common trans-eQTLs mechanism is "mediation" by a local (cis)...

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Share to Databases, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29021290
DOI: 10.1101/gr.216754.116
PMCID: PMC5668943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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