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Article

Variations and expression features of CYP2D6 contribute to schizophrenia risk.

Molecular psychiatry - 1 Jun 2021

Ma Liang, Shcherbina Anna, Chetty Sundari

Abstract excerpt

Genome-wide association studies (GWAS) have successfully identified 145 loci implicated in schizophrenia (SCZ). However, the underlying mechanisms remain largely unknown. Here, we analyze 1497 RNA-seq data in combination with their genotype data and identify SNPs that are associated with expression throughout the genome by dissecting expression features to genes (eGene) and exon-exon junctions (eJunction). Then,...

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Identifiers

PMID: 32047265
DOI: 10.1038/s41380-020-0675-y
PMCID: PMC8440189

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