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Article

Peregrination of the selectivity filter delineates the pore of the human voltage-gated proton channel hHV1.

The Journal of general physiology - 1 Dec 2013

Morgan Deri, Musset Boris, Kulleperuma Kethika, Smith Susan M E, Rajan Sindhu, Cherny Vladimir V, Pomès Régis, DeCoursey Thomas E

Abstract excerpt

Extraordinary selectivity is crucial to all proton-conducting molecules, including the human voltage-gated proton channel (hHV1), because the proton concentration is >10(6) times lower than that of other cations. Here we use "selectivity filter scanning" to elucidate the molecular requirements for proton-specific conduction in hHV1. Asp(112), in the middle of the S1 transmembrane helix, is an essential part of...

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Identifiers

PMID: 24218398
DOI: 10.1085/jgp.201311045
PMCID: PMC3840923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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