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Article

Biophysical Properties of Somatic Cancer Mutations in the S4 Transmembrane Segment of the Human Voltage-Gated Proton Channel hHV1.

Biomolecules - 21 Jan 2025

Jardin Christophe, Derst Christian, Franzen Arne, Mahorivska Iryna, DeCoursey Thomas E, Musset Boris, Chaves Gustavo

Abstract excerpt

Somatic mutations are common in cancer, with only a few driving the progression of the disease, while most are silent passengers. Some mutations may hinder or even reverse cancer progression. The voltage-gated proton channel (HV1) plays a key role in cellular pH homeostasis and shows increased expression in several malignancies. Inhibiting HV1 in cancer cells reduces invasion, migration, proton extrusion, and pH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40001460
DOI: 10.3390/biom15020156
PMCID: PMC11853527

Genes

HVCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Biophysical Properties of Somatic Cancer Mutations in the S4 Transmembrane Segment of the Human Voltage-Gated Proton Channel hHV1.PMID 40001460Read ↗

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Gating Currents in the Hv1 Proton Channel.Semantic proximity Read ↗

The pore of the voltage-gated proton channel.Semantic proximity Read ↗

Computational investigation of missense somatic mutations in cancer and potential links to pH-dependence and proteostasisSemantic proximity Read ↗

A voltage-gated proton-selective channel lacking the pore domain.Semantic proximity Read ↗

A negative-hydrated constriction zone is revealed in the active state of the Hv1 channel.Semantic proximity Read ↗

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