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Article

The pore of the voltage-gated proton channel.

Neuron - 22 Dec 2011

Berger Thomas K, Isacoff Ehud Y

Abstract excerpt

In classical tetrameric voltage-gated ion channels four voltage-sensing domains (VSDs), one from each subunit, control one ion permeation pathway formed by four pore domains. The human Hv1 proton channel has a different architecture, containing a VSD, but lacking a pore domain. Since its location is not known, we searched for the Hv permeation pathway. We find that mutation of the S4 segment's third arginine R211...

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Identifiers

PMID: 22196334
DOI: 10.1016/j.neuron.2011.11.014
PMCID: PMC3244940

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