A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels.

Abstract excerpt

Proton-gated ion channels conduct mainly Na+ to induce postsynaptic membrane depolarization. Finding the determinants of ion selectivity requires knowledge of the pore structure in the open conformation, but such information is not yet available. Here, the open conformation of the hASIC1a channel was computationally modeled, and functional effects of pore mutations were analyzed in light of the predicted...

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• Ion Channels
• Ions
• Mutation
• Protons
• Sodium