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Article

Quantitative insights into the mechanism of proton conduction and selectivity for the human voltage-gated proton channel Hv1.

Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 2024

Liu Yu, Li Chenghan, Freites J Alfredo, Tobias Douglas J, Voth Gregory A

Abstract excerpt

Human voltage-gated proton (hHv1) channels are crucial for regulating essential biological processes such as immune cell respiratory burst, sperm capacitation, and cancer cell migration. Despite the significant concentration difference between protons and other ions in physiological conditions, hHv1 demonstrates remarkable proton selectivity. Our calculations of single-proton, cation, and anion permeation free...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39259593
DOI: 10.1073/pnas.2407479121
PMCID: PMC11420211

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