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Article

Aspartate 112 is the selectivity filter of the human voltage-gated proton channel.

Nature - 23 Oct 2011

Musset Boris, Smith Susan M E, Rajan Sindhu, Morgan Deri, Cherny Vladimir V, Decoursey Thomas E

Abstract excerpt

The ion selectivity of pumps and channels is central to their ability to perform a multitude of functions. Here we investigate the mechanism of the extraordinary selectivity of the human voltage-gated proton channel, H(V)1 (also known as HVCN1). This selectivity is essential to its ability to regulate reactive oxygen species production by leukocytes, histamine secretion by basophils, sperm capacitation, and...

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Source

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Identifiers

PMID: 22020278
DOI: 10.1038/nature10557
PMCID: PMC3237871

Genes

HVCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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