From Selective Permeation to Physiology in Potassium Channels.

Abstract excerpt

Highly K+-selective potassium channels are essential for electrical signaling. The high selectivity of most K+ channels, with relative K+: Na+ permeabilities being as high as 100-1000:1 arises from the conserved so-called K+ channel selectivity filter (SF). Structural and computational studies have shown how the SF forms multiple sites that coordinate K+, by mimicking the water dipoles that coordinate K+ ions in...

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