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Article

An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1.

Nature structural & molecular biology - 1 Jul 2010

Ramsey I Scott, Mokrab Younes, Carvacho Ingrid, Sands Zara A, Sansom Mark S P, Clapham David E

Abstract excerpt

Hv1 voltage-gated proton channels mediate rapid and selective transmembrane H(+) flux and are gated by both voltage and pH gradients. Selective H(+) transfer in membrane proteins is commonly achieved by Grotthuss proton 'hopping' in chains of ionizable amino acid side chains and intraprotein water molecules. To identify whether ionizable residues are required for proton permeation in Hv1, we neutralized candidate...

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Identifiers

PMID: 20543828
DOI: 10.1038/nsmb.1826
PMCID: PMC4035905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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