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Article

Tryptophan 207 is crucial to the unique properties of the human voltage-gated proton channel, hHV1.

The Journal of general physiology - 1 Nov 2015

Cherny Vladimir V, Morgan Deri, Musset Boris, Chaves Gustavo, Smith Susan M E, DeCoursey Thomas E

Abstract excerpt

Part of the "signature sequence" that defines the voltage-gated proton channel (H(V1)) is a tryptophan residue adjacent to the second Arg in the S4 transmembrane helix: RxWRxxR, which is perfectly conserved in all high confidence H(V1) genes. Replacing Trp207 in human HV1 (hH(V1)) with Ala, Ser, or Phe facilitated gating, accelerating channel opening by 100-fold, and closing by 30-fold. Mutant channels opened at...

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Identifiers

PMID: 26458876
DOI: 10.1085/jgp.201511456
PMCID: PMC4621752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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