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Article

A voltage-gated proton-selective channel lacking the pore domain.

Nature - 27 Apr 2006

Ramsey I Scott, Moran Magdalene M, Chong Jayhong A, Clapham David E

Abstract excerpt

Voltage changes across the cell membrane control the gating of many cation-selective ion channels. Conserved from bacteria to humans, the voltage-gated-ligand superfamily of ion channels are encoded as polypeptide chains of six transmembrane-spanning segments (S1-S6). S1-S4 functions as a self-contained voltage-sensing domain (VSD), in essence a positively charged lever that moves in response to voltage changes....

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Identifiers

PMID: 16554753
DOI: 10.1038/nature04700
PMCID: PMC4084761

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