Article
Selectivity Mechanism of the Voltage-gated Proton Channel, HV1.
Scientific reports - 8 May 2015
Dudev Todor, Musset Boris, Morgan Deri, Cherny Vladimir V, Smith Susan M E, Mazmanian Karine, DeCoursey Thomas E, Lim Carmay
Abstract excerpt
Voltage-gated proton channels, HV1, trigger bioluminescence in dinoflagellates, enable calcification in coccolithophores, and play multifarious roles in human health. Because the proton concentration is minuscule, exquisite selectivity for protons over other ions is critical to HV1 function. The selectivity of the open HV1 channel requires an aspartate near an arginine in the selectivity filter (SF), a narrow...
Topics
- Arginine
- Aspartic Acid
- Humans
- Ion Channels
- Ions
- Models, Molecular
- Molecular Conformation
- Mutation
- Protein Binding
- Protons
- Tritium
- Water