Article
Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations.
The Journal of clinical investigation - 1 Nov 2013
Inoue Daichi, Kitaura Jiro, Togami Katsuhiro, Nishimura Koutarou, Enomoto Yutaka, Uchida Tomoyuki, Kagiyama Yuki, Kawabata Kimihito Cojin, Nakahara Fumio, Izawa Kumi, Oki Toshihiko, Maehara Akie, Isobe Masamichi, Tsuchiya Akiho, Harada Yuka, Harada Hironori, Ochiya Takahiro, Aburatani Hiroyuki, Kimura Hiroshi, Thol Felicitas, Heuser Michael, Levine Ross L, Abdel-Wahab Omar, Kitamura Toshio
Abstract excerpt
Recurrent mutations in the gene encoding additional sex combs-like 1 (ASXL1) are found in various hematologic malignancies and associated with poor prognosis. In particular, ASXL1 mutations are common in patients with hematologic malignancies associated with myelodysplasia, including myelodysplastic syndromes (MDSs), and chronic myelomonocytic leukemia. Although loss-of-function ASXL1 mutations promote myeloid...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.