Article

Additional Sex Combs-Like Family Associated with Epigenetic Regulation

2024-04-23

Abstract excerpt

The additional sex combs-like (ASXL) family, a mammalian homolog of the additional sex combs (Asx) of Drosophila, has been implicated in transcriptional regulation via chromatin modifications. Abnormal expression of ASXL family genes leads to myelodysplastic syndromes and various types of leukemia. De novo mutation of these genes also causes developmental disorders. Genes in this family and neighbor genes are evol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67aee44c-2edf-5f44-9526-1955397d198e
DOI: 10.20944/preprints202404.1480.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Additional Sex Combs-Like Family Associated with Epigenetic RegulationDOI 10.20944/preprints202404.1480.v1Read

Additional Sex Combs-like Family Associated with Epigenetic Regulation.Semantic proximity Read

The role of ASXL1 mutations and ASXL1 CircRNAs in cancer.Semantic proximity Read

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.Semantic proximity Read

Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia.Semantic proximity Read

ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemiaSemantic proximity Read

ASXL1/2 mutations and myeloid malignancies.Semantic proximity Read

SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesisSemantic proximity Read

Role of ASXL1 in hematopoiesis and myeloid diseases.Semantic proximity Read

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations.Semantic proximity Read

[Role of ASXL1 mutation in myeloid malignancies].Semantic proximity Read

Epigenetic regulation by ASXL1 in myeloid malignancies.Semantic proximity Read

Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.Semantic proximity Read