Article
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.
Cancer cell - 14 Aug 2012
Abdel-Wahab Omar, Adli Mazhar, LaFave Lindsay M, Gao Jie, Hricik Todd, Shih Alan H, Pandey Suveg, Patel Jay P, Chung Young Rock, Koche Richard, Perna Fabiana, Zhao Xinyang, Taylor Jordan E, Park Christopher Y, Carroll Martin, Melnick Ari, Nimer Stephen D, Jaffe Jacob D, Aifantis Iannis, Bernstein Bradley E, Levine Ross L
Abstract excerpt
Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome, myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse outcome. Despite the genetic and clinical data implicating ASXL1 mutations in myeloid malignancies, the mechanisms of transformation by ASXL1 mutations are not understood. Here, we identify that ASXL1 mutations result in loss of polycomb...
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