Article
Dual ASXL1 and CSF3R mutations drive myeloid-biased stem cell expansion and enhance neutrophil differentiation.
Blood advances - 8 Apr 2025
Darmusey Lucie, Bagley Anna J, Nguyen Thai T, Carlson Hanqian L, Blaylock Hunter, Shrestha Shawn B, Pang Amara, Tauchmann Samantha, Taylor Sarah C, Foley Amy C, Niño Katia E, Pietras Eric M, Braun Theodore P, Maxson Julia E
Abstract excerpt
ABSTRACT: Mutations in the epigenetic regulator Additional Sex Combs-Like 1 (ASXL1) are frequently observed in chronic neutrophilic leukemia (CNL). CNL is a myeloproliferative neoplasm (MPN) driven by activating mutations in the Colony Stimulating Factor 3 Receptor (CSF3R), which cause excessive neutrophil production. Despite the high rates of co-occurrence, the interplay between ASXL1 and CSF3R mutations in...
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