Article
Role of ASXL1 in hematopoiesis and myeloid diseases.
Experimental hematology - 1 Nov 2022
Gao Xin, You Xiaona, Droin Nathalie, Banaszak Lauren G, Churpek Jane, Padron Eric, Geissler Klaus, Solary Eric, Patnaik Mrinal M, Zhang Jing
Abstract excerpt
Next-generation sequencing technology, including whole-exome or whole-genome sequencing and target gene sequencing, has allowed the molecular characterization of somatic mutation spectrums in hematologic diseases. Mutations in Additional sex combs-like 1 (ASXL1), a chromatin regulator, are identified in clonal hematopoiesis of indeterminate potential (CHIP), indicating ASXL1 mutations as early events in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.