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Article

ASXL1/2 mutations and myeloid malignancies.

Journal of hematology & oncology - 6 Sept 2022

Medina Edward A, Delma Caroline R, Yang Feng-Chun

Abstract excerpt

Myeloid malignancies develop through the accumulation of genetic and epigenetic alterations that dysregulate hematopoietic stem cell (HSC) self-renewal, stimulate HSC proliferation and result in differentiation defects. The polycomb group (PcG) and trithorax group (TrxG) of epigenetic regulators act antagonistically to regulate the expression of genes key to stem cell functions. The genes encoding these proteins,...

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Source

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Identifiers

PMID: 36068610
DOI: 10.1186/s13045-022-01336-x
PMCID: PMC9450349

Genes

ASXL1
ASXL2
RUNX1
RUNX1T1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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