Article
Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice.
Blood - 23 Jan 2014
Wang Jiapeng, Li Zhaomin, He Yongzheng, Pan Feng, Chen Shi, Rhodes Steven, Nguyen Lihn, Yuan Jin, Jiang Li, Yang Xianlin, Weeks Ophelia, Liu Ziyue, Zhou Jiehao, Ni Hongyu, Cai Chen-Leng, Xu Mingjiang, Yang Feng-Chun
Abstract excerpt
ASXL1 is mutated/deleted with high frequencies in multiple forms of myeloid malignancies, and its alterations are associated with poor prognosis. De novo ASXL1 mutations cause Bohring-Opitz syndrome characterized by multiple congenital malformations. We show that Asxl1 deletion in mice led to developmental abnormalities including dwarfism, anophthalmia, and 80% embryonic lethality. Surviving Asxl1(-/-) mice lived...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.