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Article

Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia.

Blood - 7 Jan 2010

Fisher Cynthia L, Pineault Nicolas, Brookes Christy, Helgason Cheryl D, Ohta Hideaki, Bodner Caroline, Hess Jay L, Humphries R Keith, Brock Hugh W

Abstract excerpt

The Additional sex combs like 1 (Asxl1) gene is 1 of 3 mammalian homologs of the Additional sex combs (Asx) gene of Drosophila. Asx is unusual because it is required to maintain both activation and silencing of Hox genes in flies and mice. Asxl proteins are characterized by an amino terminal homo...

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Source

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Identifiers

PMID: 19861679
DOI: 10.1182/blood-2009-07-230698
PMCID: PMC2803690

Genes

ASXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19861679-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia.PMID 19861679Read ↗

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.Semantic proximity Read ↗

Additional Sex Combs-Like Family Associated with Epigenetic RegulationSemantic proximity Read ↗

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations.Semantic proximity Read ↗

Additional Sex Combs-like Family Associated with Epigenetic Regulation.Semantic proximity Read ↗

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice.Semantic proximity Read ↗

Role of ASXL1 in hematopoiesis and myeloid diseases.Semantic proximity Read ↗

[Role of ASXL1 mutation in myeloid malignancies].Semantic proximity Read ↗

Asxl1 deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors.Semantic proximity Read ↗

The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model.Semantic proximity Read ↗

Dual ASXL1 and CSF3R mutations drive myeloid-biased stem cell expansion and enhance neutrophil differentiation.Semantic proximity Read ↗

ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemiaSemantic proximity Read ↗

Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.Semantic proximity Read ↗

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