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Article

[Role of ASXL1 mutation in myeloid malignancies].

Zhongguo shi yan xue ye xue za zhi - 1 Aug 2014

Sheng Meng-Yao, Zhou Yuan, Xu Ming-Jiang, Yang Feng-Chun

Abstract excerpt

Additional sex comb-like 1 ( ASXL1) is an enhancer of Trithorax and Polycomb family, which are necessary for the maintenance of stable repression of homeotic and other loci. Recently, alterations of ASXL1 gene were identified in the hematopoietic cells from patients with a variety of myeloid malignancies, including chronic myelomonocytic leukemia (CMML, 43% of cases), myelodysplastic syndrome (MDS, 20%),...

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Topics

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Share to ASXL1 gene
Share to Leukemia, Myeloid, Acute
Share to Leukemia, Myelomonocytic, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myelodysplastic Syndromes

Share to Myeloproliferative Disorders

Share to Repressor Proteins

Source

Identifiers

PMID: 25130853
DOI: 10.7534/j.issn.1009-2137.2014.04.057

Genes

ASXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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