Article
Proton-mediated conformational changes in an acid-sensing ion channel.
The Journal of biological chemistry - 13 Dec 2013
Ramaswamy Swarna S, MacLean David M, Gorfe Alemayehu A, Jayaraman Vasanthi
Abstract excerpt
Acid-sensing ion channels are cation channels activated by external protons and play roles in nociception, synaptic transmission, and the physiopathology of ischemic stroke. Using luminescence resonance energy transfer (LRET), we show that upon proton binding, there is a conformational change that increases LRET efficiency between the probes at the thumb and finger subdomains in the extracellular domain of...
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