Article
The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6.
The Journal of biological chemistry - 12 Jul 2013
de la Roche Jeanne, Eberhardt Mirjam J, Klinger Alexandra B, Stanslowsky Nancy, Wegner Florian, Koppert Wolfgang, Reeh Peter W, Lampert Angelika, Fischer Michael J M, Leffler Andreas
Abstract excerpt
The surveillance of acid-base homeostasis is concerted by diverse mechanisms, including an activation of sensory afferents. Proton-evoked activation of rodent sensory neurons is mainly mediated by the capsaicin receptor TRPV1 and acid-sensing ion channels. In this study, we demonstrate that extracellular acidosis activates and sensitizes the human irritant receptor TRPA1 (hTRPA1). Proton-evoked membrane currents...
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