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Article

Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation.

PloS one - 1 Jan 2013

Frey Erin N, Pavlovicz Ryan E, Wegman Clem John, Li Chenglong, Askwith Candice C

Abstract excerpt

Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel that contributes to fear and pain as well as neuronal damage following persistent cerebral acidosis. Neuropeptides can affect acid-induced neuronal injury by altering ASIC1a inactivation and/or steady-state desensitization. Yet, exactly how ASIC1a inactivation and desensitization occur or are modulated by peptides is not completely understood....

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Identifiers

PMID: 23977127
DOI: 10.1371/journal.pone.0071733
PMCID: PMC3743763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation.PMID 23977127Read ↗

Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.Semantic proximity Read ↗

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Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions.Semantic proximity Read ↗

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Protonation controls ASIC1a activity via coordinated movements in multiple domains.Semantic proximity Read ↗

Conformational plasticity of human acid-sensing ion channel 1aSemantic proximity Read ↗

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