Article
A nonproton ligand sensor in the acid-sensing ion channel.
Neuron - 6 Oct 2010
Yu Ye, Chen Zhi, Li Wei-Guang, Cao Hui, Feng En-Guang, Yu Fang, Liu Hong, Jiang Hualiang, Xu Tian-Le
Abstract excerpt
Acid-sensing ion channels (ASICs) have long been considered as extracellular proton (H(+))-gated cation channels, and peripheral ASIC3 channels seem to be a natural sensor of acidic pain. Here, we report the identification of a nonproton sensor on ASIC3. We show first that 2-guanidine-4-methylquinazoline (GMQ) causes persistent ASIC3 channel activation at the normal pH. Using GMQ as a probe and combining...
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