Article

A new polymodal gating model of the proton-activated chloride channel

2022-10-31

Abstract excerpt

The proton-activated chloride (PAC) channel plays critical roles in ischemic neuron death, but its activation mechanisms remain elusive. Here, we interrogated PAC channel gating using its unique bidirectional modulator C77304 as a pharmacological probe. C77304 activated the PAC channel by acting on its proton gating, while simultaneously inhibiting channel activity at higher doses, through interaction with two mod...

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Literature Corpus work: 1a94b98a-4f94-51c3-8c93-2995f96b93b3
DOI: 10.1101/2022.10.31.514568

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