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Article

Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating.

Proceedings of the National Academy of Sciences of the United States of America - 4 Apr 2017

Vullo Sabrina, Bonifacio Gaetano, Roy Sophie, Johner Niklaus, Bernèche Simon, Kellenberger Stephan

Abstract excerpt

Acid-sensing ion channels (ASICs) are proton-activated Na+ channels expressed in the nervous system, where they are involved in learning, fear behaviors, neurodegeneration, and pain sensation. In this work, we study the role in pH sensing of two regions of the ectodomain enriched in acidic residues: the acidic pocket, which faces the outside of the protein and is the binding site of several animal toxins, and the...

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Identifiers

PMID: 28320963
DOI: 10.1073/pnas.1620560114
PMCID: PMC5389290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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