Independent contribution of extracellular proton binding sites to ASIC1a activation.

Abstract excerpt

Acid-sensing ion channels (ASICs) are a group of trimeric cation permeable channels gated by extracellular protons that are mainly expressed in the nervous system. Despite the structural information available for ASIC1, there is limited understanding of the molecular mechanism that allows these channels to sense and respond to drops in extracellular pH. In this report, we employed the substituted cysteine...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acid Sensing Ion Channels
• Share to Amino Acids
• Share to Cysteine