Article
A new polymodal gating model of the proton-activated chloride channel.
PLoS biology - 1 Sept 2023
Zhao Piao, Tang Cheng, Yang Yuqin, Xiao Zhen, Perez-Miller Samantha, Zhang Heng, Luo Guoqing, Liu Hao, Li Yaqi, Liao Qingyi, Yang Fan, Dong Hao, Khanna Rajesh, Liu Zhonghua
Abstract excerpt
The proton-activated chloride (PAC) channel plays critical roles in ischemic neuron death, but its activation mechanisms remain elusive. Here, we investigated the gating of PAC channels using its novel bifunctional modulator C77304. C77304 acted as a weak activator of the PAC channel, causing moderate activation by acting on its proton gating. However, at higher concentrations, C77304 acted as a weak inhibitor,...
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