Article

Molecular basis of proton-sensing by G protein-coupled receptors

2024-04-18

Abstract excerpt

Three proton-sensing G protein-coupled receptors (GPCRs), GPR4, GPR65, and GPR68, respond to changes in extracellular pH to regulate diverse physiology and are implicated in a wide range of diseases. A central challenge in determining how protons activate these receptors is identifying the set of residues that bind protons. Here, we determine structures of each receptor to understand the spatial arrangement of put...

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Literature Corpus work: 8e9cb927-5bea-573c-bb4c-1846ee02b533
DOI: 10.1101/2024.04.17.590000

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