Article
Distinct histidine residues control the acid-induced activation and inhibition of the cloned K(ATP) channel.
The Journal of biological chemistry - 19 Oct 2001
Xu H, Wu J, Cui N, Abdulkadir L, Wang R, Mao J, Giwa L R, Chanchevalap S, Jiang C
Abstract excerpt
The modulation of K(ATP) channels during acidosis has an impact on vascular tone, myocardial rhythmicity, insulin secretion, and neuronal excitability. Our previous studies have shown that the cloned Kir6.2 is activated with mild acidification but inhibited with high acidity. The activation relies on His-175, whereas the molecular basis for the inhibition remains unclear. To elucidate whether the His-175 is...
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