Article
Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.
Cancer cell - 11 Nov 2013
Zhang Hong, Alberich-Jorda Meritxell, Amabile Giovanni, Yang Henry, Staber Philipp B, Di Ruscio Annalisa, Diruscio Annalisa, Welner Robert S, Ebralidze Alexander, Zhang Junyan, Levantini Elena, Lefebvre Véronique, Valk Peter J M, Delwel Ruud, Hoogenkamp Maarten, Nerlov Claus, Cammenga Jörg, Saez Borja, Scadden David T, Bonifer Constanze, Ye Min, Tenen Daniel G
Abstract excerpt
Mutation or epigenetic silencing of the transcription factor C/EBPα is observed in ∼10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but downstream targets relevant for leukemogenesis are not known. Here, we identify Sox4 as a direct target of C/EBPα whereby its expression is inversely correlated with C/EBPα activity. Downregulation of Sox4...
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