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Article

C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis

23 Jun 2014

Abstract excerpt

Homeobox A9 (HOXA9) is a homeodomain-containing transcription factor that plays a key role in hematopoietic stem cell expansion and is commonly deregulated in human acute leukemias. A variety of upstream genetic alterations in acute myeloid leukemia (AML) lead to overexpression of HOXA9, almost always in association with overexpression of its cofactor meis homeobox 1 (MEIS1) . A wide range of data suggests that...

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PMID: 24958854
DOI: 10.1073/pnas.1402238111

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