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Article

Regulation of the C/EBPα signaling pathway in acute myeloid leukemia (Review)

10 Mar 2015

Abstract excerpt

The transcription factor CCAAT/enhancer binding protein α (C/EBPα), as a critical regulator of myeloid development, directs granulocyte and monocyte differentiation. Various mechanisms have been identified to explain how C/EBPα functions in patients with acute myeloid leukemia (AML). C/EBPα expression is suppressed as a result of common leukemia-associated genetic and epigenetic alterations such as AML1-ETO,...

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PMID: 25760953
DOI: 10.3892/or.2015.3848

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