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Article

SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia

15 Nov 2012

Abstract excerpt

The Sox4 transcription factor mediates early B-cell differentiation. Compared with normal pre-B cells, SOX4 promoter regions in Ph(+) ALL cells are significantly hypomethylated. Loss and gain-of-function experiments identified Sox4 as a critical activator of PI3K/AKT and MAPK signaling in ALL cells. ChIP experiments confirmed that SOX4 binds to and transcriptionally activates promoters of multiple components...

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PMID: 23152540
DOI: 10.1182/blood-2012-05-428938

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