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Article

C/EBPα deregulation as a paradigm for leukemogenesis.

Leukemia - 1 Nov 2017

Pulikkan J A, Tenen D G, Behre G

Abstract excerpt

Myeloid master regulator CCAAT enhancer-binding protein alpha (C/EBPα) is deregulated by multiple mechanisms in leukemia. Inhibition of C/EBPα function plays pivotal roles in leukemogenesis. While much is known about how C/EBPα orchestrates granulopoiesis, our understanding of molecular transformation events, the role(s) of cooperating mutations and clonal evolution during C/EBPα deregulation in leukemia remains...

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Identifiers

PMID: 28720765
DOI: 10.1038/leu.2017.229
PMCID: PMC8197657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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