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Article

C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia.

Blood advances - 13 Feb 2018

Loke Justin, Chin Paulynn Suyin, Keane Peter, Pickin Anna, Assi Salam A, Ptasinska Anetta, Imperato Maria Rosaria, Cockerill Peter N, Bonifer Constanze

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous disease caused by recurrent mutations in the transcription regulatory machinery, resulting in abnormal growth and a block in differentiation. One type of recurrent mutations affects RUNX1, which is subject to mutations and translocations, the latter giving rise to fusion proteins with aberrant transcriptional activities. We recently compared the mechanism by which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Leukemic

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Source

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Identifiers

PMID: 29431622
DOI: 10.1182/bloodadvances.2017012781
PMCID: PMC5812331

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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